ALZ-801

Names

[ Name ]:
ALZ-801

[Synonym ]:
GHG2B47067

Biological Activity

[Description]:

ALZ-801 is an orally available, small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease[2].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

β-amyloid[1]

[References]

[1]. John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861.

[2]. Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₈N₂O₄S

[ Molecular Weight ]:
238.302

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.