H-Leu-Leu-Leu-OH

Names

[ Name ]:
H-Leu-Leu-Leu-OH

[Synonym ]:
L-LEUCY-L-LEUCYL-L-LEUCINE
tri-leucine
LEU-LEU-LEU
MFCD00038309
Leucylleucylleucin
Leu-leu-leucrystalline
L-LEUCYL-L-LEUCYL-L-LEUCINE
L-LEUCYLLEUCYLLEUCINE
leucyl-leucyl-leucine
H-LEU-LEU-LEU-OH

Biological Activity

[Description]:

(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.057g/cm3

[ Boiling Point ]:
589.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₃₅N₃O₄

[ Molecular Weight ]:
357.48800

[ Flash Point ]:
310.4ºC

[ Exact Mass ]:
357.26300

[ PSA ]:
121.52000

[ LogP ]:
2.98830

[ Vapour Pressure ]:
1.99E-15mmHg at 25°C

[ Index of Refraction ]:
1.488

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Proc. Natl. Acad. Sci. U. S. A. 107 , 18143-18148, (2010)

Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tu...

Trileucine improves aerosol performance and stability of spray-dried powders for inhalation.

J. Pharm. Sci. 97 , 287-302, (2008)

For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of...

Temozolomide delivery to tumor cells by a multifunctional nano vehicle based on poly(β-L-malic acid).

Pharm. Res. 27 , 2317-2329, (2010)

Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited ...