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Napyradiomycin A1

Names

[ CAS No. ]:
103106-24-7

[ Name ]:
Napyradiomycin A1

[Synonym ]:
2H-Naphtho(2,3-b)pyran-5,10-dione,3,4a-dichloro-10a-(3,7-dimethyl-2,6-octadienyl)-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl
2H-Naphtho(2,3-b)pyran-5,10-dione,3,4,4a,10a-tetrahydro-3,4a-dichloro-10a-(3,7-dimethyl-2,6-octadienyl)-6,8-dihydroxy-2,2-dimethyl
Napyradiomycin A
Napyradiomycin A1

Biological Activity

[Description]:

Napyradiomycin A1 is one enantioselective compound of napyradiomycins. napyradiomycins are an intriguing family of halogenated natural products with activity against several tumor cell lines as well as some bacterial strains[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Scott A Snyder, et al. Enantioselective total synthesis of (-)-napyradiomycin A1 via asymmetric chlorination of an isolated olefin. J Am Chem Soc. 2009 Apr 29;131(16):5744-5.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
642.5ºC at 760mmHg

[ Molecular Formula ]:
C25H30Cl2O5

[ Molecular Weight ]:
481.40900

[ Flash Point ]:
342.4ºC

[ Exact Mass ]:
480.14700

[ PSA ]:
83.83000

[ LogP ]:
6.08230

[ Vapour Pressure ]:
4.17E-17mmHg at 25°C

[ Index of Refraction ]:
1.595

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL6128600
CHEMICAL NAME :
2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4,4a,10a-tetrahydro-3,4a-dichloro-10a-(3,7-dimethyl -2,6- octadienyl)-6,8-dihydroxy-2,2-dimethyl-
CAS REGISTRY NUMBER :
103106-24-7
LAST UPDATED :
199212
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H30-Cl2-O5
MOLECULAR WEIGHT :
481.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,487,1986

Related Compounds

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