B 746

Names

[ Name ]:
B 746

[Synonym ]:
3-Aethylamino-2-(4-chlor-anilino)-5-(4-chlor-phenyl)-phenazinium-betain
CF Deriv B746
3-p-Chloroanilino-10-(p-chlorophenyl)-2-(ethylimino)-2,10-dihydrophenazine
B 746
3-ethylamino-2-(4-chloro-anilino)-5-(4-chloro-phenyl)-phenazinium-betaine

Biological Activity

[Description]:

B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

B746（1、3、10 μM；7 天）显著抑制分枝杆菌的生长[1]。

[In Vivo]

B746 （口服；10、20、30 mg/kg；单剂量；第一天和第 2、4 和 6 周）抑制米色小鼠脾脏中的分枝杆菌生长[1]。 Animal Model: beige mice Dosage: 10, 20, 30 mg/kg Administration: p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 week after infection Result: Reduced Colony Forming Units (CFU) counts of Mycobacteria in spleen of beige mice.

[References]

[1]. Gangadharam PR, et al. In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex. Tuber Lung Dis. 1992 Aug;73(4):192-9.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
561.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₂₀Cl₂N₄

[ Molecular Weight ]:
459.37

[ Flash Point ]:
293.4ºC

[ Exact Mass ]:
458.10700

[ PSA ]:
42.21000

[ LogP ]:
7.22270

[ Vapour Pressure ]:
1.24E-12mmHg at 25°C

[ Index of Refraction ]:
1.674

Related Compounds

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