2',3',5'-triacetyl-5-Azacytidine

Names

[ Name ]:
2',3',5'-triacetyl-5-Azacytidine

[Synonym ]:
4-amino-1-(2,3,5-tri-O-acetylpentofuranosyl)-1,3,5-triazin-2(1H)-one
2',3',5'-triacetyl-5-Azacytosine
1,3,5-Triazin-2(1H)-one,4-amino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)
2,3,5-tri-O-acetyl-5-azacytidine
5-azacytidine triacetate
4-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-
2',3',5'-triacetyl-5-azacytidine

Biological Activity

[Description]:

2′,3′,5′-Triacetyl-5-azacytidine is an orally active prodrug of 5-Azacytidine. 5-Azacytidine is an inhibitor of DNA methyltransferase[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> DNA Methyltransferase

[References]

[1]. Ziemba A, et, al. Development of an oral form of azacytidine: 2'3'5'triacetyl-5-azacytidine. Chemother Res Pract. 2011;2011:965826.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
497.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₈N₄O₈

[ Molecular Weight ]:
370.315

[ Flash Point ]:
254.6±31.5 °C

[ Exact Mass ]:
370.112457

[ PSA ]:
161.93000

[ LogP ]:
-0.60

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.634

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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