L 888607 Racemate

Names

[ Name ]:
L 888607 Racemate

[Synonym ]:
l-888,291
l-883,595

Biological Activity

[Description]:

L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Research Areas >> Inflammation/Immunology

[Target]

DP/DP1:132 nM (Ki)

TP:17 nM (Ki)

[In Vitro]

L 888607 Racemate (compound 3) maintains a modest binding affinity for the DP1 receptor (Ki = 132 nM) and is actually 8-fold more potent on the TP receptor (Ki = 17 nM)[1].

[References]

[1]. Beaulieu C, et al. Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700.

[Related Small Molecules]

Dinoprostone | Prostaglandin E1 | E7046 | ONO-AE3-208 | PF 04418948 | Fevipiprant | grapiprant | TG6-10-1 | Taprenepag | GW 627368 | MRE-269 | Ramatroban | AH 6809 | Laropiprant | AZD1981

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅ClFNO₂S

[ Molecular Weight ]:
375.84400

[ Exact Mass ]:
375.05000

[ PSA ]:
67.53000

[ LogP ]:
5.54700

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%