Retreversine

Names

[ Name ]:
Retreversine

[Synonym ]:
N-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
1H-Purine-2,6-diamine, N-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-

Biological Activity

[Description]:

Retreversine is an inactive control for Reversine. Reversine is a novel class of ATP-competitive Aurora kinase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[References]

[1]. Bijian K, et, al. Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine. Br J Cancer. 2013 Nov 26;109(11):2810-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
571.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₇N₇O

[ Molecular Weight ]:
393.485

[ Flash Point ]:
299.7±32.9 °C

[ Exact Mass ]:
393.227722

[ PSA ]:
94.22000

[ LogP ]:
0.56

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.740

Related Compounds

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