MMP145

Names

[ Name ]:
MMP145

Biological Activity

[Description]:

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Wei Li,Jianchang Li,Yuchuan Wu,Fabio Rancati,Stefania Vallese,Luca Raveglia ,Junjun Wu ,Rajeev Hotchandani,Nathan Fuller,Kristina Cunningham ,Paul Morgan ,Susan Fish,Rustem Krykbaev , Xin Xu , Steve Tam , Samuel J. Goldman , William Abraham , Cara Williams,Joseph Sypek and Tarek S.Mansour.Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of AsthmaJ. Med. Chem., 2009, 52 (17), pp 5408–5419.

[2]. Li W, et, al. Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem. 2009 Sep 10;52(17):5408-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀N₂O₇S

[ Molecular Weight ]:
432.44700

[ Exact Mass ]:
432.09900

[ PSA ]:
134.53000

[ LogP ]:
4.46680

Related Compounds

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