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Pseudoprotodioscin

Names

[ CAS No. ]:
102115-79-7

[ Name ]:
Pseudoprotodioscin

[Synonym ]:
PSEUDOPROTOTRIBESTIN
β-D-Glucopyranoside, (25R)-3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy]furosta-5,20(22)-dien-27-yl
(3β,25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->;2)-[6-deoxy-α-L-mannopyranosyl-(1->;4)]-β-D-glucopyranoside
pseudo-Protodioscin
PROTODIOSCIN,PSEUDO
β-D-Glucopyranoside, (25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1-&gt;2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-
(25R)-26-(β-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside
Pseduoprotodioscin
(25R)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranosyl]oxy}furosta-5,20(22)-dien-27-yl β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-
Pseudoprotodioscin

Biological Activity

[Description]:

Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA
Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Research Areas >> Metabolic Disease

[In Vitro]

In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].

[References]

[1]. Gai Y, et al. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393.

[2]. Liang ZZ, et al. Oligofurostanosides from Asparagus cochinchinensis. Planta Med. 1988 Aug;54(4):344-6.

Chemical & Physical Properties

[ Density]:
1.45 g/cm3

[ Molecular Formula ]:
C51H82O21

[ Molecular Weight ]:
1031.184

[ Exact Mass ]:
1030.534912

[ PSA ]:
325.83000

[ LogP ]:
5.31

[ Index of Refraction ]:
1.631

Safety Information

[ Safety Phrases ]:
S24/25

[ HS Code ]:
29389090

Related Compounds