Anecortave

Names

[ Name ]:
Anecortave

[Synonym ]:
21-Desacetyl Anecortave
17,21-Dihydroxy-pregna-4,9(11)-dien-3,20-dion
17,21-dihydroxy-pregna-4,9(11)-diene-3,20-dione
(8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Biological Activity

[Description]:

Anecortave (AL-4940) is an angiogenesis inhibitor. Anecortave is indicated for the study of exudative (wet) age-related macular degeneration as well as retinal tumors[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Kaiser PK, et al. Posterior juxtascleral depot administration of anecortave acetate. Surv Ophthalmol. 2007 Jan;52 Suppl 1:S62-9.

[2]. Jockovich ME, et al. Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1264-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈O₄

[ Molecular Weight ]:
344.44

[ Exact Mass ]:
344.19900

[ PSA ]:
74.60000

[ LogP ]:
2.73090

Anecortave

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds