Clazuril

Names

[ Name ]:
Clazuril

[Synonym ]:
CLAZURIL
Clazurilum [Latin]
[2-chloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl](4-chlorophenyl)acetonitrile
Clazurilo [Spanish]
Clazuril (USAN/INN)
Clazurilo
Clazurilum

Biological Activity

[Description]:

Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle[1].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Clazuril (2.5 mg/pigeon) results in a rapid suppression of oocyst excretion, but oocysts are again observed in the feces 20 days after treatment. The fact that oocysts appears again in the feces 3 to 5 weeks after treatment can probably be explained only by a persistence of endogenous stages, which are not affected during treatment, rather than by a reinfection [2].

[References]

[1]. W Coussement, et al. Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons. Res Vet Sci. 1988 Jul;45(1):117-9.

[2]. J Vercruysse, et al. Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. Jan-Mar 1990;34(1):73-9.

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Melting Point ]:
196.8°

[ Molecular Formula ]:
C₁₇H₁₀Cl₂N₄O₂

[ Molecular Weight ]:
373.19300

[ Exact Mass ]:
372.01800

[ PSA ]:
91.54000

[ LogP ]:
2.88308

[ Index of Refraction ]:
1.692

Synthetic Route

Click to get detail synthetic route

Articles

Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge.

J. Zoo Wildl. Med. 36(3) , 391-400, (2005)

The anticoccidial efficacy of amprolium, clazuril, and monensin were studied in sandhill cranes (Grus canadensis) infected with a mixture of Eimeria spp. oocysts. Five groups of four 1-day-old sandhil...

Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons.

Res. Vet. Sci. 45(1) , 117-9, (1988)

Racing pigeons were artificially infected with a mixed inoculum of Eimeria labbeana (85 per cent) and E columbarum (15 per cent) and treated orally with 2.5 mg clazuril either on day 1, 2, 3, 4, 5, 6 ...

Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons.

Avian Dis. 34(1) , 73-9, (1990)

The efficacy of toltrazuril in comparison with clazuril on heavy experimental Eimeria labbeana and E. columbarum infections in pigeons was investigated. The minimum required dose of toltrazuril to com...

Related Compounds

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