H-Ala-Ala-Ala-Ala-Ala-OH

Names

[ Name ]:
H-Ala-Ala-Ala-Ala-Ala-OH

[Synonym ]:
D-Penta-L-Alanine
L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanine
Ala-(Ala)3-Ala
ALA-ALA-ALA-ALA-ALA
PENTA-ALA
PENTA-L-ALANINE
L-ALA-ALA-ALA-ALA-ALA

Biological Activity

[Description]:

Penta-alanine (Penta-L-alanine) is a petide. Penta-alanine can be used for neurological disease research[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Niu L, et al. Transformation of β-sheet structures of the amyloid peptide induced by molecular modulators. Chem Commun (Camb). 2014 Aug 18;50(64):8923-6.

[2]. Mu Y, et al. Energy landscape of a small peptide revealed by dihedral angle principal component analysis. Proteins. 2005 Jan 1;58(1):45-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₇N₅O₆

[ Molecular Weight ]:
373.40500

[ Exact Mass ]:
373.19600

[ PSA ]:
179.72000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Protein dynamical transition does not require protein structure.

Phys. Rev. Lett. 101 , 178103, (2008)

Terahertz time domain spectroscopy shows that the protein dynamical transition, the rapid increase in protein dynamics occurring at approximately 200 K, needs neither tertiary nor secondary structure....

Using J-coupling constants for force field validation: application to hepta-alanine.

J. Phys. Chem. B 115 , 15221-15227, (2011)

A computational solution to the protein folding problem is the holy grail of biomolecular simulation and of the corresponding force fields. The complexity of the systems used for folding simulations p...

Resampling improves the efficiency of a "fast-switch" equilibrium sampling protocol.

J. Chem. Phys. 130 , 081102, (2009)

We recently applied a multistage reweighting scheme to demonstrate the sampling of equilibrium configurational distributions of peptides from nonequilibrium, simulated annealing trajectories [E. Lyman...

Related Compounds

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