Curvularin

Names

[ Name ]:
Curvularin

[Synonym ]:
curvularin

Biological Activity

[Description]:

Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[Target]

IC50: 9.5 µM (iNOS)[2].

[References]

[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122.

[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
557ºC at 760mmHg

[ Melting Point ]:
205-207 °C

[ Molecular Formula ]:
C₁₆H₂₀O₅

[ Molecular Weight ]:
292.32700

[ Flash Point ]:
207.9ºC

[ Exact Mass ]:
292.13100

[ PSA ]:
83.83000

[ LogP ]:
2.71880

[ Vapour Pressure ]:
5.18E-13mmHg at 25°C

[ Index of Refraction ]:
1.54

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.

J. Nat. Prod. 76(11) , 2145-9, (2013)

Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicill...

Metabolite production by differentUlocladiumspecies

Int. J. Food Microbiol. 126(1-2) , 172-9, (2008)

Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agent...

[Molecular basis of probes for cytoskeletal proteins].

Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993)