5-[(3-{[(4R)-6,8-Dibromo-3,4-dihydro-2H-chromen-4-yl]amino}propyl )amino]thieno[3,2-b]pyridin-7(4H)-one dihydrochloride

Names

[ Name ]:
5-[(3-{[(4R)-6,8-Dibromo-3,4-dihydro-2H-chromen-4-yl]amino}propyl )amino]thieno[3,2-b]pyridin-7(4H)-one dihydrochloride

Biological Activity

[Description]:

CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Agent with Minimal Disruption of Normal Gut Microbiota. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01395-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁Br₂Cl₂N₃O₂S

[ Molecular Weight ]:
586.16800

[ Exact Mass ]:
582.91000

[ PSA ]:
97.88000

[ LogP ]:
6.85910

Related Compounds

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