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Simvastatin Hydroxy Acid Sodium Salt

Names

[ CAS No. ]:
101314-97-0

[ Name ]:
Simvastatin Hydroxy Acid Sodium Salt

[Synonym ]:
Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate
Simvastatin Hydroxy Acid Sodium Salt
simvastatin sodium
Si-Methyl-N,N'N''-triphenyl-silantriyltriamin
1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1)
trianilino-methyl-silane
simvastatin sodium salt
Silanetriamine,1-methyl-N,N',N''-triphenyl
Methyl-tris-anilino-silan
simivastin sodium salt
Simvastatin EP Impurity A Sodium Salt
Simvastatin Impurity 1

Biological Activity

[Description]:

Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Research Areas >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1]. Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1].

[In Vivo]

Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1].

[References]

[1]. Corsini A, et al. Pharmacology of competitive inhibitors of HMG-CoA reductase.Pharmacol Res. 1995 Jan;31(1):9-27.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H39NaO6

[ Molecular Weight ]:
458.563

[ Exact Mass ]:
458.264435

[ PSA ]:
106.89000

[ LogP ]:
2.77100

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds