Tenovin-3

Names

[ Name ]:
Tenovin-3

[Synonym ]:
N-[(4-Aminophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide
QC-514
1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea
N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide
Benzamide, N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)-
Tenovin-3

Biological Activity

[Description]:

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

[Related Catalog]:

Signaling Pathways >> Apoptosis >> MDM-2/p53

Research Areas >> Cancer

[References]

[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.

[Related Small Molecules]

Pifithrin-α hydrobromide | RG7388 | Nutlin-3a | AMG232 | Pifithrin-β (hydrobromide) | Stylomycin aminonucleoside | RG7112 | APR-246 | NVP-HDM201 | SAR 405838 | RITA (NSC 652287) | NVP-CGM097 | Tenovin-1 | SJ 172550

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₂₁N₃OS

[ Molecular Weight ]:
327.444

[ Exact Mass ]:
327.140533

[ PSA ]:
109.77000

[ LogP ]:
2.82

[ Appearance of Characters ]:
yellow solid

[ Index of Refraction ]:
1.662

[ Storage condition ]:
-20℃

Related Compounds

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