1011301-27-1

1011301-27-1 structure

Name: Tenovin-3
Chemical Name: N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
CAS Number: 1011301-27-1
Molecular Formula: C₁₈H₂₁N₃OS
Molecular Weight: 327.444
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2018-11-14 21:14:38
Modify Date: 2024-01-04 11:52:39
Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

Name	N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
Synonyms	N-[(4-Aminophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide QC-514 1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide Benzamide, N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)- Tenovin-3

Description	Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]
Related Catalog	Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
References	[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.