3'-beta-Azido-2',3'-dideoxyuridine

Names

[ Name ]:
3'-beta-Azido-2',3'-dideoxyuridine

[Synonym ]:
HMS2234N04
AZU(up)
AZddU (threo)

Biological Activity

[Description]:

3'-beta-Azido-2',3'-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₁N₅O₄

[ Molecular Weight ]:
253.21

[ Exact Mass ]:
253.08100

[ PSA ]:
134.33000