Artemisitene

Names

[ Name ]:
Artemisitene

[Synonym ]:
artemisitene (methyl artemisinin)

Biological Activity

[Description]:

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[In Vitro]

Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2].

[In Vivo]

In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1].

[References]

[1]. Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30(7):2500-10.

[2]. Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37(37):5079-5087.

Chemical & Physical Properties

[ Melting Point ]:
160-162°C (lit.)

[ Molecular Formula ]:
C₁₅H₂₀O₅

[ Molecular Weight ]:
280.32

[ Exact Mass ]:
280.13100

[ PSA ]:
53.99000

[ LogP ]:
2.31500

[ Vapour Pressure ]:
3.52E-07mmHg at 25°C

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.