Trisodium phosphate dodecahydrate

Names

[ Name ]:
Trisodium phosphate dodecahydrate

[Synonym ]:
trisodium,phosphate,dodecahydrate
Sodium phosphate,tribasic dodecahydrate
MFCD00149198
Sodium phosphate hydrate (3:1:12)
Phosphoric acid, trisodium salt, dodecahydrate
Trisodium phosphate dodecahydrate
Sodium phosphate tribasic dodecahydrate
EINECS 231-509-8
Phosphoric acid trisodium salt dodecahydrate
Sodium phosphate dodecahydrate

Biological Activity

[Description]:

Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Armstrong R D, et al. Behaviour of sodium silicate and sodium phosphate (tribasic) as corrosion inhibitors for iron[J]. Journal of applied electrochemistry, 1994, 24: 1244-1248.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.62

[ Boiling Point ]:
158ºC at 760 mmHg

[ Melting Point ]:
75 °C

[ Molecular Formula ]:
H₂₄Na₃₆O₁₆P

[ Molecular Weight ]:
380.18

[ Exact Mass ]:
380.049500

[ PSA ]:
206.82000

[ Index of Refraction ]:
1.4458

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong acids. Keep dry.

[ Water Solubility ]:
258 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TC9575000

CHEMICAL NAME :: Phosphoric acid, trisodium salt, dodecahydrate

CAS REGISTRY NUMBER :: 10101-89-0

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: O4-P.3Na.12H2-O

MOLECULAR WEIGHT :: 380.18

WISWESSER LINE NOTATION :: NA3 P-O4 &QH 12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 257,791,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1585 No. of Facilities: 154 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 308 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1585 No. of Facilities: 3662 (estimated) No. of Industries: 36 No. of Occupations: 31 No. of Employees: 31308 (estimated) No. of Female Employees: 6999 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R35

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3262 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TC9575000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2835291000

Customs

[ HS Code ]: 2835291000

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