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Blasticidin A

Names

[ CAS No. ]:
100513-53-9

[ Name ]:
Blasticidin A

[Synonym ]:
2H-Pyran, 2-dodecyltetrahydro-6-(15,17,21-trimethyltricosyl)-
2-Dodecyl-6-(15,17,21-trimethyltricosyl)tetrahydro-2H-pyran

Biological Activity

[Description]:

Blasticidin A ((+)-Blasticidin A) is an inhibitor of Aflatoxin production by Aspergillus parasiticus. Blasticidin A almost completely inhibits Aflatoxin production at 0.5 μM[1]. Blasticidin A is a potent antibiotic produced by Streptomyces, inhibits Aflatoxin production without strong growth inhibition toward Aflatoxin-producing fungi[2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. S Sakuda, et al. Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. J Antibiot (Tokyo). 2000 Nov;53(11):1265-71.

[2]. Tomoya Yoshinari, et al. Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors. J Antibiot (Tokyo). 2010 Jun;63(6):309-14.

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
610.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C43H86O

[ Molecular Weight ]:
619.142

[ Flash Point ]:
269.1±19.5 °C

[ Exact Mass ]:
618.667847

[ LogP ]:
20.45

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.458

Related Compounds