Rustmicin

Names

[ Name ]:
Rustmicin

[Synonym ]:
Galbonolide
Rustmicin
Galbonolide A
Erythronolide A,6,7,10,11,12,20-hexadehydro-6-demethyl-9-deoxo-3,5,11,12-tetradeoxy-4,17-dihydroxy-6-O-methyl-3-oxo

Biological Activity

[Description]:

Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Rustmicin (0-32 µg/mL; 24-48 h) 显示抗真菌活性，对 Cryptococcus neoformans MY1051, Cryptococcus neoformans MY1146, Cryptococcus neoformans MY2061, Cryptococcus neoformans MY2062, C. parapsilosis (MY1010), C. pseudotropicalis (MY2099), C. krusei (MY549), C. tropicalis (MY1012) 菌株的 MIC 值分别为 0.002, 0.001, 0.0001, 0.0002, 0.015, 0.015, 0.031, 0.031 µg/mL[1]。

[In Vivo]

Rustmicin (0、10、20、40、80 mg/kg；腹腔注射；每天两次，持续 4 天) 在隐球菌病小鼠模型中显示出抗真菌活性[1]。 Animal Model: DBA/2N mice (Cryptococcus neoformans MY2061)[1] Dosage: 0, 10, 20, 40, 80 mg/kg Administration: I.p.; twice daily for 4 days Result: Showed a dose-dependent reduction in colony-forming units isolated from spleen and brain tissue of mice, with the ED99 value of 29 mg/kg for both tissues.

[References]

[1]. Mandala SM, et al. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J Biol Chem. 1998 Jun 12;273(24):14942-9.

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
581.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₃₂O₆

[ Molecular Weight ]:
380.47500

[ Flash Point ]:
198.1ºC

[ Exact Mass ]:
380.22000

[ PSA ]:
93.06000

[ LogP ]:
2.69950

[ Vapour Pressure ]:
6.03E-16mmHg at 25°C

[ Index of Refraction ]:
1.518

Related Compounds

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