100227-57-4

100227-57-4 structure

Name: Rustmicin
Chemical Name: (3R,7Z,9S,12E,14S)-14-ethyl-5-hydroxy-5-(hydroxymethyl)-7-methoxy-3,9,13-trimethyl-11-methylidene-1-oxacyclotetradeca-7,12-diene-2,4-dione
CAS Number: 100227-57-4
Molecular Formula: C₂₁H₃₂O₆
Molecular Weight: 380.47500
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2017-10-21 20:30:56
Modify Date: 2025-09-22 11:05:02
Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity[1].

Name	(3R,7Z,9S,12E,14S)-14-ethyl-5-hydroxy-5-(hydroxymethyl)-7-methoxy-3,9,13-trimethyl-11-methylidene-1-oxacyclotetradeca-7,12-diene-2,4-dione
Synonyms	Galbonolide Rustmicin Galbonolide A Erythronolide A,6,7,10,11,12,20-hexadehydro-6-demethyl-9-deoxo-3,5,11,12-tetradeoxy-4,17-dihydroxy-6-O-methyl-3-oxo

Description	Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Rustmicin (0-32 µg/mL; 24-48 h) 显示抗真菌活性，对 Cryptococcus neoformans MY1051, Cryptococcus neoformans MY1146, Cryptococcus neoformans MY2061, Cryptococcus neoformans MY2062, C. parapsilosis (MY1010), C. pseudotropicalis (MY2099), C. krusei (MY549), C. tropicalis (MY1012) 菌株的 MIC 值分别为 0.002, 0.001, 0.0001, 0.0002, 0.015, 0.015, 0.031, 0.031 µg/mL[1]。
In Vivo	Rustmicin (0、10、20、40、80 mg/kg；腹腔注射；每天两次，持续 4 天) 在隐球菌病小鼠模型中显示出抗真菌活性[1]。 Animal Model: DBA/2N mice (Cryptococcus neoformans MY2061)[1] Dosage: 0, 10, 20, 40, 80 mg/kg Administration: I.p.; twice daily for 4 days Result: Showed a dose-dependent reduction in colony-forming units isolated from spleen and brain tissue of mice, with the ED99 value of 29 mg/kg for both tissues.
References	[1]. Mandala SM, et al. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J Biol Chem. 1998 Jun 12;273(24):14942-9.