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Flazin

Names

[ CAS No. ]:
100041-05-2

[ Name ]:
Flazin

[Synonym ]:
Flazine
3-carboxylperlolyrine
Flazin
9H-Pyrido[3,4-b]indole-3-carboxylic acid,1-[5-(hydroxymethyl)-2-furanyl]

Biological Activity

[Description]:

Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Research Areas >> Neurological Disease

[Target]

IC50: 85.31 μM (BSA), 0.51 mM (XOD)[1][2] EC50: 71.99 μM (ONOO-)[1]


[In Vitro]

Flazin significantly decreases cellular triglyceride (TG) by 12.0-22.4% compared with modeling groups and improved the TG and free fatty acid profile[2]. Flazin efficiently reduces both cellular neutral lipid content by 17.4-53.9% and lipid droplets size by 10.0-35.3%[2]. Flazin exhibits xanthine oxidase inhibitory with an IC50 of 0.51 mM[3].

[References]

[1]. Seong SH, et al. Discovery of Flazin, an Alkaloid Isolated from Cherry Tomato Juice, As a Novel Non-Enzymatic Protein Glycation Inhibitor viain Vitro and in Silico Studies. J Agric Food Chem. 2021 Mar 31;69(12):3647-3657.

[2]. Wu X, et al. Flazin as a Lipid Droplet Regulator against Lipid Disorders. Nutrients. 2022 Apr 3;14(7):1501.

[3]. Li H, et al. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. J Agric Food Chem. 2016 Jun 15;64(23):4725-34.

Chemical & Physical Properties

[ Density]:
1.513g/cm3

[ Boiling Point ]:
657.1ºC at 760mmHg

[ Molecular Formula ]:
C17H12N2O4

[ Molecular Weight ]:
308.28800

[ Flash Point ]:
351.2ºC

[ Exact Mass ]:
308.08000

[ PSA ]:
99.35000

[ LogP ]:
3.16660

[ Vapour Pressure ]:
3.69E-18mmHg at 25°C

[ Index of Refraction ]:
1.771

Related Compounds