Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

…, S Evgenevich Tkachenko, A Khvat

Index: Ivachtchenko, Alexandre Vasilevich; Frolov, Eugene Borisovich; Mitkin, Oleg Dmitrievich; Tkachenko, Sergey Evgenevich; Khvat, Alexandre Letters in Drug Design and Discovery, 2010 , vol. 7, # 6 p. 446 - 451

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Abstract

In the present paper, we describe the synthesis and biological evaluation for a series of novel 6, 9-disubstituted 2-methyl-1, 2, 3, 4, 5, 6-hexahydroazepino [4, 3-b] indoles. These compounds represent unique bioisosteric analogues of Dimebon™ with promising biological activity against a panel of various targets including some GPCR family members.

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