Small peptides as modular catalysts for the direct asymmetric aldol reaction: ancient peptides with aldolase enzyme activity

W Zou, I Ibrahem, P Dziedzic, H Sundén…

Index: Zou, Weibiao; Ibrahem, Ismail; Dziedzic, Pawel; Sunden, Henrik; Cordova, Armando Chemical Communications, 2005 , # 39 p. 4946 - 4948

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Citation Number: 81

Abstract

Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes.