Novel synthetic 2-amino-10-(3, 5-dimethoxy) benzyl-9 (10H)-acridinone derivatives as potent DNA-binding antiproliferative agents
C Gao, F Liu, X Luan, C Tan, H Liu, Y Xie, Y Jin…
Index: Gao, Chunmei; Liu, Feng; Luan, Xudong; Tan, Chunyan; Liu, Hongxia; Xie, Yonghua; Jin, Yibao; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7507 - 7514
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Citation Number: 26
Abstract
A series of novel 9 (10H)-acridinone derivatives with terminal amino substituents at C2 position on the acridinone ring were synthesized and studied for their antiproliferative activity and underlying mechanisms. These compounds demonstrated promising cytotoxicity to leukemia cells CCRF-CEM, displaying IC50 values in the low micromolar range. Structure– activity relationships (SAR) indicated that the compound 6d bearing a pyrrolidine ...
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