Synlett

Azole-N-acetonitriles as carbonyl synthons: A one-pot preparation of heteroaryl amides from halides

Z Zhang, Z Yin, JF Kadow, NA Meanwell, T Wang

Index: Zhang, Zhongxing; Yin, Zhiwei; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao Synlett, 2004 , # 13 p. 2323 - 2326

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Citation Number: 3

Abstract

Abstract Azole-N-acetonitrile derivatives were utilized as synthons for an ambident carbonyl moiety via a strategy relying upon sequential base-mediated SN Ar substitution of a 2-halo heterocycle, in situ oxidation, and amine displacement. This strategy allows prompt and efficient synthesis of N-containing heteroaryl amides directly from the corresponding halides via a one-pot process.