Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast.

Carlos Ramos, Martha Montaño, Jose Cisneros, Bettina Sommer, Javier Delgado, Georgina Gonzalez-Avila

Index: Exp. Lung Res. 33(3-4) , 151-67, (2007)

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Abstract

Substance P is involved in inflammatory processes, but its effect on extracellular matrix metabolism has not been studied; therefore, the authors evaluated its effect on collagen synthesis and degradation, expression of pro-alpha1(I) collagen, matrix metalloproteinase-1 and -2, and tissue inhibitor of metalloproteinase-1 and -2 in normal human lung fibroblast strains. Substance P induced a decrease in collagen biosynthesis, concomitant to a down-regulation of pro-alpha1(I) collagen mRNA. In contrast, an increase in collagen degradation was observed, accompanied with an up-regulation of matrix metalloproteinase-1. Substance P did not influence tissue inhibitor of metalloproteinase-1 and -2 or matrix metalloproteinase-2 expression. The results suggest that substance P participates in extracellular matrix metabolism.