An expedient enzymatic route to isomeric 2-, 3- and 6-monodeoxy-monofluoro-maltose derivatives.

Krit Tantanarat, Martin Rejzek, Ellis O'Neill, Christian Ruzanski, Lionel Hill, Shirley A Fairhurst, Tipaporn Limpaseni, Robert A Field

Index: Carbohydr. Res. 358 , 12-8, (2012)

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Abstract

2-Deoxy-2-fluoro-d-glucose, 3-deoxy-3-fluoro-D-glucose and 6-deoxy-6-fluoro-D-glucose were converted into the corresponding maltose derivatives using Arabidopsis thaliana DPE2-mediated trans-glycosylation reaction with glycogen acting as a glucosyl donor. (19)F NMR spectroscopy proved to be a valuable tool for monitoring the progress of these reactions and to assess the nature of resulting oligomeric products.Copyright © 2012 Elsevier Ltd. All rights reserved.