Human & Experimental Toxicology 1990-05-01

Specific anti-digoxin Fab fragments: an available antidote for proscillaridin and scilliroside poisoning?

A Sabouraud, M Urtizberea, N Cano, R Garnier, J M Scherrmann

Index: Hum. Exp. Toxicol. 9(3) , 191-3, (1990)

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Abstract

The purpose of this study was to evaluate the capacity of specific anti-digoxin Fab fragments to bind to and neutralize scilliroside and proscillaridin in acute poisoning. Apparent affinity constants were determined with values of 2.6 10(8)M-1 for scilliroside and 3.8 10(7)M-1 for proscillaridin. These results are in accordance with a possible in-vivo neutralization of these toxins.

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