[Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias].

T V Bershova, M I Bakanov, L A Bokeriia, V I Serbin, T N Mamedova, I L Mikhaĭlova

Index: Vopr. Med. Khim. 40(4) , 50-3, (1994)

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Abstract

Regulation of intracellular calcium homeostasis by means of secondary mediators calmodulin and 4,5-inositol phosphates (products of phosphatidyl inositol hydrolysis) was studied in children with ectopic forms of arrhythmias. Alterations in the system calmodulin-Ca2+ and the activity of phosphoinosite metabolism correlated highly with clinical manifestations of the arrhythmias. The data obtained suggest that a number of molecular mechanisms and responsible for arrhythmias were realized in cell membranes and depended on a complex of intracellular messengers affected within various steps of the hormonal signal transmission.