Dihydrocytosines and cytokines from 3??aminopropionitriles
L Doub, U Krolls
Index: Doub,L.; Krolls,U. Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 527 - 535
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Citation Number: 8
Abstract
Abstract The synthesis of dihydrocytosines 4 from 3-aminopropionitriles 1 has been broadened and the dihydrocytosines themselves have now been successfully converted to cytosines 9. Unsubstituted 3-(H, alkyl or aryl) aminopropionitriles (1, X= H) convert with cyanate to 1-(H, alkyl or aryl)-1-(2-cyanoethyl) ureas (2, X= H), which in turn easily cyclize with anhydrous strong acid or base to 1-(H, alkyl or aryl)-5, 6-dihydrocytosines (4, X= H). ...
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