Organic Letters 2009-01-15

Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.

Laura Rubio-Pérez, F Javier Pérez-Flores, Pankaj Sharma, Luis Velasco, Armando Cabrera

Index: Org. Lett. 11 , 265-268, (2009)

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Abstract

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.