A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives.
Gang Zhou, Pauline Ting, Robert Aslanian, John J Piwinski
Index: Org. Lett. 10(12) , 2517-20, (2008)
Full Text: HTML
Abstract
A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed alpha-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.
Related Compounds
Related Articles:
2004-04-02
[J. Org. Chem. 69(7) , 2461-8, (2004)]
Total synthesis of (±)-heliannuol D, an allelochemical from Helianthus annuus. Vyvyan JR and Looper RE.
[Tetrahedron Lett. 41(8) , 1151-1154, (2000)]
(Bmim) Br3 as a New Reagent for Regioselective Monobromination of Phenols and Several Activated Aromatics under Solvent-free Conditions. Le ZG, et al.
[Chin. J. Chem. 23(11) , 1537-1540, (2005)]
The isopropyl cresols. Carpenter MS and Easter WM.
[J. Org. Chem. 20(4) , 401-411, (1955)]