Palladium-catalyzed formylation of aryl halides with tert-butyl isocyanide.
Xiao Jiang, Jin-Mei Wang, Ying Zhang, Zhong Chen, Yong-Ming Zhu, Shun-Jun Ji
Index: Org. Lett. 16(13) , 3492-5, (2014)
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Abstract
A novel palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH has been demonstrated, which provides a strategy toward important aldehydes with moderate to excellent yield. The advantage of this reaction includes milder conditions, convenient operation, lower toxicity, and wide functional group tolerance.
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