Journal of Organic Chemistry
2009-10-02
Concise synthesis of PM-94128 and Y-05460M-A.
Masaru Enomoto, Shigefumi Kuwahara
Index: J. Org. Chem. 74(19) , 7566-9, (2009)
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Abstract
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved from N-Boc-l-valine by the same approach, which enabled its stereochemical determination.
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