Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Mahbub Alam, Rebekah E Beevers, Tom Ceska, Richard J Davenport, Karen M Dickson, Mara Fortunato, Lewis Gowers, Alan F Haughan, Lynwen A James, Mark W Jones, Natasha Kinsella, Christopher Lowe, Johannes W G Meissner, Anne-Lise Nicolas, Benjamin G Perry, David J Phillips, William R Pitt, Adam Platt, Andrew J Ratcliffe, Andrew Sharpe, Laura J Tait
Index: Bioorg. Med. Chem. Lett. 17 , 3463, (2007)
Full Text: HTML
Abstract
The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
Related Compounds
Related Articles:
2007-07-26
[J. Med. Chem. 50 , 3497, (2007)]
One-pot Double Suzuki Couplings of Dichloropyrimidines.
2012-02-01
[Synthesis 2010(16) , 2721-2724, (2010)]
2006-01-19
[Org. Lett. 8(2) , 269-72, (2006)]
2011-07-18
[Chem. Res. Toxicol. 24(7) , 1003-11, (2011)]
2004-05-28
[J. Org. Chem. 69 , 3943-3949, (2004)]