Arzneimittel-Forschung 1977-01-01

[Antiviral agents / 9th communication: virustatically active N-(1-adamantyl)-thiourea derivatives based on cyclic secondary amines (author's transl)].

A Kreutzberger, H H Schröders

Index: Arzneimittelforschung 27(5) , 969-72, (1977)

Full Text: HTML

Abstract

By nucleophilic addition of pyrrolidine (2a), piperidine (2b), 3-hydroxypiperidine (2c), and 4-hydroxypiperidine (2d) on 1-adamantyl-isothiocyanate (1), the N',N'-disubstituted N-(1-adamantyl)-thiourea derivatives 3a, 3b, 3c, and 3d are accessible. Particularly 3d exhibits remarkable antiviral activity vaccinia and herpes virus.

Related Compounds

Related Articles:

7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.

2013-01-01

[Molecules 18(2) , 2397-418, (2013)]

Synthesis and structural characterization of tris(2-mercapto-1-adamantylimidazolyl)hydroborato complexes: a sterically demanding tripodal [S3] donor ligand.

2011-12-19

[Inorg. Chem. , (2011)]

More Articles...