Study of spontaneous and acid hydrolysis of Nibuphin

AI Razumov, RI Tarasova, VG Nikolaeva…

Index: Razumov, A. I.; Tarasova, R. I.; Nikolaeva, V. G.; Syrneva, L. P. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 5 p. 404 - 405 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 5 p. 607 - 609

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Abstract

The medicinal preparation Nibuphin (p-nitrophenyl ester of dibutylphosphinic acid, I) is used in medical practice in the form of 0.033% aqueous solutions as a myotic and antiglaucoma agent [i]. During storage of the medicinal form of the preparation, a gradual decrease in its activity is observed. It is known that p-nitrophenyl esters of carboxylic acids [2] and tetracoordinated phosphorus acids [3] readily hydrolyze. The IR and UV spectral ...