Nucleophilic substitution reaction at the 1-position of 1-hydroxytryptamine and-tryptophan derivatives

F Yamada, A Goto, W Peng, T Hayashi…

Index: Yamada, Fumio; Goto, Aya; Peng, Wu; Hayashi, Toshikatsu; Saga, Yoshitomo; Somei, Masanori Heterocycles, 2003 , vol. 61, p. 163 - 172

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Citation Number: 5

Abstract

抄録: A novel nucleophilic substitution reaction at the 1-position of indole nucleus was discovered by reacting 1-hydroxytryptamine and-tryptophan derivatives with indoles in 85% formic acid yielding 1-(indol-3-yl) indoles. Their structures were determined by X-Ray crystallographic analysis and chemical correlations. An SN2 mechanism on the indole nitrogen (1-position) is proposed.

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