Tetrahedron

Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin

Q Zhang, G Cheng, YZ Huang, GR Qu, HY Niu…

Index: Zhang, Qian; Cheng, Gang; Huang, Yong-Zhen; Qu, Gui-Rong; Niu, Hong-Ying; Guo, Hai-Ming Tetrahedron, 2012 , vol. 68, # 38 p. 7822 - 7826

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Citation Number: 7

Abstract

Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity> 99: 1 was attributed to the β-cyclodextrin cavity blocked the N7 of purines ring.

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