Utility of purinyl radicals in the synthesis of base-modified nucleosides and alkylpurines: 6-amino group replacement by hydrogen, chlorine, bromine, and iodine

V Nair, SG Richardson

Index: Nair, Vasu; Richardson, Stephen G. Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 3969 - 3974

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Citation Number: 106

Abstract

Older synthetic procedures for nebularine (la) involved chloromercuripurinide fusion reactions with sugar derivatives such as chlorc~ triacetoribofuranose,~ modified fusion reactions, 6 and longer syntheses involving catalytic hydrogenation of ring-halogenated materials7 or of thioinosine. 8 Access to 9-alkylpurines from 9-alkyladenines or from other corresponding purines was previously limited. Such routes included alkylation of purine ...