An environmentally friendly and cost effective synthesis of estradiol featuring two novel reagents: Si (0)/KF and PMHS/hexamethyldisiloxane/pTSA
C Lim, GN Evenson, WR Perrault, BA Pearlman
Index: Lim, Chongsoo; Evenson, Gerald N.; Perrault, William R.; Pearlman, Bruce A. Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6417 - 6420
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Citation Number: 10
Abstract
Si (0)/KF is introduced as a strong, inexpensive, environmentally friendly, and safe reagent for 'dissolving metal'-type reduction. PMHS/hexamethyldisiloxane/pTSA is introduced as an inexpensive substitute for Et3SiH/TFA for 'ionic hydrogenation', where the hexamethyldisiloxane functions as a capping agent to block the oligomeric silicone by- product from cross-linking to a gel, rubber, or plastic. An environmentally friendly and cost ...
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