New synthesis of estradiol from androsta-1, 4-diene-3, 17-dione
…, DM Kochev, MA Lapitskaya, KK Pivnitsky
Index: Vasiljeva; Demin; Kochev; Lapitskaya; Pivnitsky Russian Chemical Bulletin, 1999 , vol. 48, # 3 p. 593 - 595
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Citation Number: 2
Abstract
Abstract A new method for the aromatization of ring A in androsta-1, 4-diene-3, 17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1, 4-diene-3, 17-dione to the corresponding dienediol followed by double C, O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.
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