One-Pot Reduction of Sulfoxides with NaBH4, CoCl2· 6H2O Catalyst, and Moist Alumina
S Yakabe, M Hirano, T Morimoto
Index: Yakabe, Shigetaka; Hirano, Masao; Morimoto, Takashi Synthetic Communications, 2011 , vol. 41, # 15 p. 2251 - 2255
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Citation Number: 3
Abstract
Abstract Sulfoxides are reduced by a combination of sodium borohydride, a catalytic amount of cobalt (II) chloride hexahydrate, and chromatographic neutral alumina preloaded with a small amount of water (moist alumina) in hexane to produce the corresponding sulfides in good to excellent yields under mild conditions. An interesting structural influence of sulfoxides on their reactivity is observed.
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