New fluorine-containing hydrazones active against MDR-tuberculosis

E Vavříková, S Polanc, M Kočevar, K Horváti…

Index: Vavrikova, Eva; Polanc, Slovenko; Kocevar, Marijan; Horvati, Kata; Bsze, Szilvia; Stolarikova, Jirina; Vavrova, Katerina; Vinsova, Jarmila European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 4937 - 4945

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Citation Number: 28

Abstract

Several new fluorine-containing hydrazones were synthesized and screened for their in vitro antimycobacterial activity. Nine of these derivatives have shown a remarkable activity against MDR-TB strain with MIC 0.5 μg/mL and high value of selectivity index (SI). Compound 3h with the highest SI (1268.58) was used for stability evaluation with putative metabolites (ciprofloxacin and formylciprofloxacin) detection. Compound 3h was stable at ...