Archives Internationales de Pharmacodynamie et Therapie 1980-09-01

Effects of halopemide on potassium-induced release of radiolabeled neurotransmitters from rat cerebrocortical slices in vitro.

A J Loonen, W Soudijn

Index: Arch. Int. Pharmacodyn. Ther. 247(1) , 43-58, (1980)

Full Text: HTML

Abstract

The effects of halopemide on the release of 3H-serotonin, 3H-noradrenaline, 3H-acetylcholine and 3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous 3H-serotonin and to a lesser extend 3H-noradrenaline outflow were augmented by the agents, while the effects on basal 3H-acetylcholine and 3H-GABA release were small or absent. Mechanism explaining these effects are discussed. Depolarization-induced release of serotonin was affected more markedly than the extra overflow of other radiolabeled transmitters, but the statistical significant of the response was limited.

Related Compounds

Related Articles:

CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation.

2013-12-01

[Purinergic Signal. 9(4) , 609-19, (2013)]

Halopemide, a new psychotropic agent. Cerebral distribution and receptor interactions.

1985-02-22

[Pharm. Weekbl. Sci. 7(1) , 1-9, (1985)]

Dynamic cation-exchange systems for the separation of drugs derived from butyrophenone and diphenylpiperidine by high-performance liquid chromatography and applied in the determination of halopemide in plasma.

[J. Chromatogr. A. 164(2) , 177-85, (1979)]

Endocrine effects of domperidone: a peripheral dopamine blocking agent.

1981-09-01

[Clin. Endocrinol. (Oxf.) 15(3) , 275-82, (1981)]

Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier.

1986-01-01

[Psychopharmacology 89(1) , 108-12, (1986)]

More Articles...