Bioorganic & Medicinal Chemistry Letters 2008-06-15

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

George M Buckley, Richard Fosbeary, Joanne L Fraser, Lewis Gowers, Alicia P Higueruelo, Lynwen A James, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin

Index: Bioorg. Med. Chem. Lett. 18(12) , 3656-60, (2008)

Full Text: HTML

Abstract

Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.

Related Compounds

Related Articles:

Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.

2013-12-20

[Org. Lett. 15(24) , 6254-7, (2013)]

One-pot three-component synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridine derivatives using air as an oxidant.

2012-09-01

[Chem. Asian J. 7(9) , 2028-31, (2012)]

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.

2007-01-01

[Bioorg. Med. Chem. 15(1) , 403-12, (2007)]

Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs.

2011-05-01

[Eur. J. Med. Chem. 46 , 1874, (2011)]

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.

2006-11-01

[Bioorg. Med. Chem. Lett. 16(21) , 5598-601, (2006)]

More Articles...