Structure–function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells
Emanuel Berger, Dirk Haller
Index: Biochem. Biophys. Res. Commun. 409 , 610, (2011)
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Abstract
Highlights ► TUDCA inhibits the expression of ER stress markers in intestinal epithelial cells. ► TUDCA prohibits the activation of the unfolded protein response in these cells. ► UDCA but not taurine mediates the inhibitory effects of TUDCA. ► The hydrophobic parts of TUDCA prohibit the aggregation of denatured proteins.
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